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KMID : 1059520180620010030
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Journal of the Korean Chemical Society
2018 Volume.62 No. 1 p.30 ~ p.35
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Development of Hydrogel for Decrease Protein Adsorption and Application to Intraocular Lens
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Ko Na-Young
Lee Hyun-Mee
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Abstract
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The purpose of this study was to decrease the protein adsorption and improve the function of the hydrophobic acrylic Intraocular lens(IOL). Hydrophobic acrylic intraocular lenses were prepared by using ethyleneglycol phenyletheracrylate (EGPEA), styrene and 2-hydroxyethyl methacrylate (HEMA). Polyvinyl pyrrolidone (PVP) and 2-methacryloyloxyethyl phosphorylcholine (MPC) were used as additives. Water contents, wettability, light transmittance and protein adsorption amount were measured to evaluate the physical properties of the intraocular lens. The water content and wettability of all samples containing additives were increased and the amount of protein adsorption decreased. In particular, samples containing MPC showed a further decrease in protein adsorption. The hydrophobic acrylic intraocular lens with PVP and MPC was found to improve the function of the intraocular lens by reducing the protein adsorption while having basic physical properties.
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KEYWORD
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Intraocular lens, PVP, MPC, Wettability, Protein adsorption
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